{"id":681,"date":"2024-09-09T15:48:44","date_gmt":"2024-09-09T06:48:44","guid":{"rendered":"https:\/\/tenbainet.com\/?page_id=38"},"modified":"2025-11-29T17:15:49","modified_gmt":"2025-11-29T08:15:49","slug":"research","status":"publish","type":"page","link":"https:\/\/www7.kmu.ac.jp\/eye\/?page_id=681","title":{"rendered":"\u7814\u7a76\u7d39\u4ecb"},"content":{"rendered":"

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\n\u81e8\u5e8a\u7814\u7a76\u3067\u306f\u3001\u7279\u6b8a\u5916\u6765\u30c1\u30fc\u30e0\u3092\u4e2d\u5fc3\u3068\u3057\u3066\u3001\u305d\u308c\u305e\u308c\u306e\u5bfe\u8c61\u75be\u60a3\u306b\u3064\u3044\u3066\u3001\u624b\u8853\u6cd5\u306e\u9055\u3044\u306b\u3088\u308b\u8996\u529b\u4e88\u5f8c\u306e\u5dee\u3084\u65b0\u85ac\u306e\u52b9\u679c\u78ba\u8a8d\u3001\u65b0\u3057\u3044\u75be\u60a3\u6982\u5ff5\u306b\u3088\u308b\u8a3a\u65ad\u306e\u78ba\u7acb\u306a\u3069\u3001\u6570\u3005\u306e\u81e8\u5e8a\u7814\u7a76\u3092\u884c\u3044\u3001\u5185\u5916\u306b\u7a4d\u6975\u7684\u306b\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u81e8\u5e8a\u7814\u7a76<\/a>
\n\u57fa\u790e\u7814\u7a76<\/a><\/div>\n
\n
\n

\u81e8\u5e8a\u7814\u7a76<\/h2>\n

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\uff08\u60c5\u5831\u516c\u958b\u6587\u66f8\uff09<\/a><\/span><\/p>\n

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\uff08\u60c5\u5831\u516c\u958b\u6587\u66f8\uff09<\/a><\/span>
\n\u2192\u3000\u3076\u3069\u3046\u819c\u708e\u521d\u8a3a\u60a3\u8005\u306e\u591a\u65bd\u8a2d\u5171\u540c\u75ab\u5b66\u8abf\u67fb
\uff08\u60c5\u5831\u516c\u958b\u6587\u66f8\uff09<\/a><\/span><\/p>\n

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\u89d2\u819c\u75be\u60a3\u306b\u5bfe\u3059\u308b\u81e8\u5e8a\u7814\u7a76<\/h3>\n

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\n\u2464\u3000\u514e\u773c\u3001\u4e09\u53c9\u795e\u7d4c\u9ebb\u75fa\u306a\u3069\u6613\u611f\u67d3\u6027\u72b6\u614b\u306b\u304a\u3051\u308b\u6cbb\u7642\u6cd5\u306e\u958b\u767a
\n\u2465\u3000\u611f\u67d3\u6027\u75be\u60a3\u306e\u8a3a\u65ad\u30fb\u6cbb\u7642\u4e88\u5f8c\u306b\u3064\u3044\u3066\u306f\u3001\u65e5\u672c\u773c\u611f\u67d3\u75c7\u5b66\u4f1a\u4e3b\u5c0e\u306e\u5171\u540c\u7814\u7a76\u3082\u9032\u3081\u3066\u3044\u307e\u3059\u3002
\n\u4e00\u65b9\u3001\u975e\u611f\u67d3\u6027\u306e\u75be\u60a3\u3067\u306f\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u3084\u30a2\u30c8\u30d4\u30fc\u306b\u4f34\u3046\u89d2\u819c\u969c\u5bb3\u3001\u30e2\u30fc\u30ec\u30f3\u6f70\u760d\u3084GVHD\uff08\u79fb\u690d\u7247\u5bfe\u5bbf\u4e3b\u75c5\uff09\u3001\u773c\u8868\u9762\u816b\u760d\u306a\u3069\u306f\u3001\u305d\u308c\u305e\u308c\u76ae\u819a\u79d1\u3001\u81a0\u539f\u75c5\u5185\u79d1\u3001\u8840\u6db2\u816b\u760d\u5185\u79d1\u3001\u653e\u5c04\u7dda\u79d1\u306a\u3069\u3068\u5bc6\u306b\u9023\u643a\u3057\u3001\u6cbb\u7642\u306b\u52aa\u3081\u307e\u3059\u3002\u975e\u611f\u67d3\u6027\u75be\u60a3\u306b\u3064\u3044\u3066\u3082\u3001\u3088\u308a\u7684\u78ba\u306a\u6cbb\u7642\u3092\u76ee\u6307\u3057\u3001\u7d50\u819c\u30ea\u30f3\u30d1\u816b\u304a\u3088\u3073\u82e5\u5e74\u708e\u75c7\u6027\u6bcd\u6591\u306e\u6cbb\u7642\u4e88\u5f8c\u306e\u691c\u8a0e\u306a\u3069\u306e\u81e8\u5e8a\u7814\u7a76\u3092\u9042\u884c\u4e2d\u3067\u3059\u3002<\/p>\n<\/div>\n<\/section>\n

\u57fa\u790e\u7814\u7a76<\/h2>\n

\u75c5\u614b\u89e3\u660e\u3084\u6cbb\u7642\u306a\u3069\u306e\u300c\u81e8\u5e8a\u306b\u76f4\u7d50\u3059\u308b\u30c6\u30fc\u30de\u300d\u3092\u4e2d\u5fc3\u306b\u57fa\u790e\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059<\/p>\n

\u6ef2\u51fa\u578b\u52a0\u9f62\u9ec4\u6591\u5909\u6027\u306b\u95a2\u3059\u308b\u52d5\u7269\u7814\u7a76<\/h3>\n

\u6ef2\u51fa\u578b\u52a0\u9f62\u9ec4\u6591\u5909\u6027 (age-related macular degeneration: AMD)\u306e\u4e3b\u75c5\u5909\u3067\u3042\u308b\u8108\u7d61\u819c\u65b0\u751f\u8840\u7ba1(choroidal neovascularization: CNV)\u306e\u767a\u751f\u306b\u306f\u69d8\u3005\u306a\u56e0\u5b50\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u5897\u6b96\u56e0\u5b50(vascular endothelial growth factor: VEGF)\u306f\u305d\u306e\u4e2d\u3067\u3082\u7279\u306b\u6ce8\u76ee\u3055\u308c\u3001\u6297VEGF\u6297\u4f53\u306b\u3088\u308b\u6cbb\u7642\u304cAMD\u6cbb\u7642\u306e\u4e2d\u5fc3\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u4e00\u65b9\u3067\u3001\u6297VEGF\u7642\u6cd5\u304c\u7121\u52b9\u306a\u75c7\u4f8b\u3084\u3001\u6cbb\u7642\u52b9\u679c\u306b\u4e4f\u3057\u3044\u62b5\u6297\u4f8b\u304c\u4e00\u5b9a\u6570\u898b\u3089\u308c\u3001\u6211\u3005\u306f\u7dda\u7dad\u82bd\u7d30\u80de\u5897\u6b96\u56e0\u5b502(basic fibroblast growth factor 2 : FGF2)\u306b\u7740\u76ee\u3057\u3066\u3044\u307e\u3057\u305f\u3002VEGF\u304c\u6ce8\u76ee\u3055\u308c\u308b\u4ee5\u524d\u304b\u3089\u3001FGF2\u306fCNV\u306e\u767a\u751f\u3084\u6210\u719f\u3001\u9000\u7e2e\u306b\u5bc4\u4e0e\u3059\u308b\u3068\u3044\u3046\u5831\u544a\u304c\u591a\u6570\u3042\u308a\u307e\u3059\u304c\u3001\u8a73\u7d30\u306f\u672a\u3060\u306b\u4e0d\u660e\u78ba\u306a\u70b9\u304c\u591a\u3044\u3067\u3059\u3002FGF2\u304cCNV\u306e\u3042\u3089\u3086\u308b\u904e\u7a0b (\u767a\u751f\u30fb\u767a\u80b2\u30fb\u9000\u7e2e) \u3067\u5bc6\u63a5\u306b\u95a2\u4fc2\u304c\u3042\u308b\u3082\u306e\u306e\u3001\u540c\u4e00\u500b\u4f53\u3067\u306e\u7d99\u6642\u7684\u306a\u5909\u5316\u306e\u691c\u8a0e\u304c\u306a\u3055\u308c\u3066\u3044\u306a\u3044\u3053\u3068\u304c\u3001\u7814\u7a76\u306e\u969c\u58c1\u3068\u3057\u3066\u6319\u3052\u3089\u308c\u307e\u3059\u3002\u5f53\u7814\u7a76\u5ba4\u306f\u3001\u907a\u4f1d\u5b50\u6539\u5909\u306b\u3088\u3063\u3066FGF2\u3092\u7db2\u819c\u8996\u7d30\u80de\u306e\u307f\u306b\u767a\u73fe\u3059\u308b\u30e2\u30c7\u30eb\u30de\u30a6\u30b9(\u4ee5\u4e0b\u3001FGF2-tg)\u3092\u4fdd\u6709\u3057\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u52d5\u7269\u5c02\u7528\u306e\u5149\u5e72\u6e09\u65ad\u5c64\u8840\u7ba1\u64ae\u5f71\u6a5f\u5668\uff08optical coherence tomography angiography\uff1bOCTA)\u3092\u6709\u3057\u3066\u3044\u307e\u3059\u3002OCTA\u306f\u975e\u4fb5\u8972\u7684\u306b\u8840\u7ba1\u3092\u64ae\u50cf\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u305f\u3081\u3001\u540c\u4e00\u500b\u4f53\u3067\u306e\u7d99\u6642\u7684\u306a\u5909\u5316\u3092\u89b3\u5bdf\u3067\u304d\u308b\u753b\u671f\u7684\u306a\u6a5f\u5668\u3067\u3059\u3002\u672c\u7814\u7a76\u306f\u3053\u308c\u3089\u3092\u6d3b\u7528\u3057\u3001FGF2-tg\u3067\u30ec\u30fc\u30b6\u30fc\u3092\u7528\u3044\u305fAMD\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u3092\u4f5c\u6210\u5f8cOCTA\u3067\u64ae\u5f71\u3057\u3001\u91ce\u751f\u578b\u30de\u30a6\u30b9\u3068\u6bd4\u8f03\u3057\u307e\u3057\u305f\u3002FGF2\u306e\u8840\u7ba1\u3078\u306e\u4f5c\u7528\u306f\u3001\u65b0\u751f\u8840\u7ba1\u306e\u6210\u9577\u904e\u7a0b\u306e\u3069\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u3067\u4f5c\u7528\u3059\u308b\u304b\u306b\u3088\u308a\u5927\u304d\u304f\u5909\u308f\u3063\u3066\u304f\u308b\u3053\u3068\u3092\u540c\u4e00\u500b\u4f53\u3067\u7d99\u6642\u7684\u306b\u89b3\u5bdf\u3057\u3001\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u4eca\u5f8c\u306f\u3001\u60a3\u8005\u306e\u8840\u7ba1\u306e\u72b6\u614b\u306b\u5fdc\u3058\u305f\u30aa\u30fc\u30c0\u30fc\u30e1\u30a4\u30c9\u304b\u3064\u3001\u6297VEGF\u7642\u6cd5\u4e00\u8fba\u5012\u306e\u73fe\u72b6\u3092\u6253\u7834\u3059\u308b\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n

\u672a\u719f\u5150\u7db2\u819c\u75c7\u306b\u95a2\u3059\u308b\u52d5\u7269\u7814\u7a76<\/h3>\n

\u672a\u719f\u5150\u7db2\u819c\u75c7\u306f\u3001\u672a\u719f\u5150\u306b\u304a\u3051\u308b\u8996\u899a\u969c\u5bb3\u306e\u4e3b\u8981\u306a\u539f\u56e0\u3067\u3042\u308a\u3001\u7db2\u819c\u8840\u7ba1\u306e\u767a\u80b2\u304c\u7d42\u4e86\u3057\u3066\u3044\u306a\u3044\u65e9\u7523\u5150\u3078\u306e\u9ad8\u9178\u7d20\u6295\u4e0e\u306b\u3088\u3063\u3066\u6b63\u5e38\u306a\u8840\u7ba1\u767a\u80b2\u304c\u963b\u5bb3\u3055\u308c\u3001\u7121\u8840\u7ba1\u9818\u57df\u304b\u3089\u8840\u7ba1\u5185\u76ae\u5897\u6b96\u56e0\u5b50\uff08VEGF: Vascular Endothelial Growth Factor\uff09\u304c\u767a\u73fe\u3059\u308b\u3053\u3068\u3067\u7570\u5e38\u306a\u7db2\u819c\u8840\u7ba1\u304c\u8a98\u767a\u3055\u308c\u308b\u3053\u3068\u3092\u7279\u5fb4\u3068\u3057\u307e\u3059\u3002\u73fe\u5728\u3001\u672a\u719f\u5150\u7db2\u819c\u75c7\u306e\u6cbb\u7642\u306b\u306f\u30ec\u30fc\u30b6\u30fc\u5149\u51dd\u56fa\u3084\u6297VEGF\u85ac\u6ce8\u5c04\u304c\u7528\u3044\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u3053\u308c\u3089\u306f\u5bfe\u51e6\u7642\u6cd5\u3067\u3042\u308a\u6839\u672c\u6cbb\u7642\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u79c1\u305f\u3061\u306e\u7814\u7a76\u3067\u306f\u3001\u8840\u5c0f\u677f\u7531\u6765\u6210\u9577\u56e0\u5b50-A\uff08PDGF-A: Platelet-Derived Growth Factor-A\uff09\u767a\u73fe\u907a\u4f1d\u5b50\u6539\u5909\u30de\u30a6\u30b9\u3092\u7528\u3044\u3066\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u63a2\u308a\u307e\u3057\u305f\u3002PDGF-A\u306f\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306e\u767a\u73fe\u3092\u5897\u5f37\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306f\u6b63\u5e38\u306a\u8840\u7ba1\u6210\u9577\u306e\u92f3\u578b\u3068\u306a\u308a\u3001\u8840\u7ba1\u3068\u30e6\u30cb\u30c3\u30c8\u3092\u5f62\u6210\u3057\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u6539\u5909\u30de\u30a6\u30b9\u3092\u7528\u3044\u305f\u672a\u719f\u5150\u7db2\u819c\u75c7\u30e2\u30c7\u30eb\u3067\u306f\u3001\u91ce\u751f\u578b\u30de\u30a6\u30b9\u3088\u308a\u3082\u9855\u8457\u306b\u8840\u7ba1\u9000\u7e2e\u306e\u6291\u5236\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u6210\u679c\u306f\u3001PDGF-A\u304cROP\u306e\u65b0\u305f\u306a\u6cbb\u7642\u6a19\u7684\u3068\u306a\u308b\u53ef\u80fd\u6027\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u4eca\u5f8c\u3001PDGF-A\u3092\u57fa\u76e4\u3068\u3057\u305f\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n

Reis-B\u00fccklers\u89d2\u819c\u30b8\u30b9\u30c8\u30ed\u30d5\u30a3\u3092\u4e2d\u5fc3\u3068\u3057\u305fTGFBI\u95a2\u9023\u89d2\u819c\u30b8\u30b9\u30c8\u30ed\u30d5\u30a3\u306e\u65b0\u898f\u6cbb\u7642\u6cd5\u306e\u958b\u767a<\/h3>\n

TGFBI\u95a2\u9023\u89d2\u819c\u30b8\u30b9\u30c8\u30ed\u30d5\u30a3\u306f\u5e38\u67d3\u8272\u4f53\u512a\u6027\u907a\u4f1d\u5f62\u5f0f\u3092\u3068\u308b\u907a\u4f1d\u6027\u75be\u60a3\u3067\u3042\u308a\u3001\u672c\u90a6\u306b\u304a\u3051\u308b\u6709\u75c5\u7387\u306f\u304a\u3088\u305d1\u4e07\u4eba\u306b3\u4eba\u3067\u3059\u3002\u3053\u306e\u75be\u60a3\u3067\u306f\u3001\u89d2\u819c\u306b\u4e0d\u8981\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u84c4\u7a4d\u3059\u308b\u305f\u3081\u306b\u3001\u8996\u529b\u4f4e\u4e0b\u304c\u751f\u3058\u307e\u3059\u3002\u3053\u306eTGFBI\u95a2\u9023\u89d2\u819c\u30b8\u30b9\u30c8\u30ed\u30d5\u30a3\u306e\u4e2d\u3067\u3082RBCD (Reis-B\u00fccklers corneal dystrophy; R124L)\u306f\u5e7c\u5c11\u671f\u3088\u308a\u767a\u75c7\u3057\u3001\u89d2\u819c\u304c\u6fc1\u308a\u3001\u8996\u529b\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002
\n\u73fe\u884c\u306eRBCD\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u6cd5\u3068\u3057\u3066\u306f\u3001\u30ec\u30fc\u30b6\u30fc\u306b\u3088\u308b\u89d2\u819c\u5207\u9664\u3001\u89d2\u819c\u96fb\u6c17\u5206\u89e3\u304a\u3088\u3073\u8868\u5c64\u89d2\u819c\u79fb\u690d\u8853\u306a\u3069\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u52b9\u679c\u306f\u9650\u5b9a\u7684\u3067\u3042\u308a\u5bfe\u75c7\u7642\u6cd5\u306e\u57df\u3092\u51fa\u307e\u305b\u3093\u3002\u73fe\u5728\u3001\u6211\u3005\u306f\u3001\u3053\u306eRBCD\u306b\u7126\u70b9\u3092\u3042\u3066\u3001\u75c5\u614b\u89e3\u6790\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002\u5177\u4f53\u7684\u306b\u306f\u95a2\u897f\u533b\u79d1\u5927\u5b66iPS\u5e79\u7d30\u80de\u30fb\u518d\u751f\u533b\u5b66\u8b1b\u5ea7\uff08\u4eba\u898b\u6d69\u53f2\u6559\u6388\uff09\u3068\u306e\u5171\u540c\u7814\u7a76\u3068\u3057\u3066\u3001TGFBI\u907a\u4f1d\u5b50\u5909\u7570\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u89d2\u819c\u30b8\u30b9\u30c8\u30ed\u30d5\u30a3\u60a3\u8005\u3088\u308aiPS\u7d30\u80de\u3092\u6a39\u7acb\u3057\u3001\u5206\u5316\u8a98\u5c0e\u3057\u305f\u773c\u30aa\u30eb\u30ac\u30ce\u30a4\u30c9\u3092\u7528\u3044\u3066\u3001\u305d\u306e\u75c5\u614b\u3092\u518d\u73fe\u3059\u308b\u3053\u3068\u3067\u3001\u767a\u75c7\u6a5f\u69cb\u306e\u89e3\u660e\u304a\u3088\u3073\u65b0\u898f\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

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