研究業績

Publication & Invited Symposiums, Lectures and Talks list

査読付原著論文

Peer-reviewed English Original Articles

2024年

Fukushima H, Takao S, Furusawa A, Valera Romero V, Gurram S, Kato T, Okuyama
S, Kano M, Choyke PL, Kobayashi H.
Theranostic near-infrared photoimmunotherapy targeting Nectin-4 in bladder cancer
preclinical models.
Cancer Letters 2024; In press.
Kobayashi T, Noma K, Kato T, Nishiwaki N, Ohara T, Nishimura S, Kunitomo T,
Kawasaki K, Akai M, Komoto S, Kashima H, Kikuchi S, Tazawa H, Shirakawa Y, Choyke
PL, Kobayashi H, Fujiwara T.
Near-infrared Photoimmunotherapy Targeting Cancer-Associated Fibroblasts in PatientDerived Xenograft models using a Humanized anti-Fibroblast Activation Protein ntibody
Molecular Cancer Therapeutics 2024; In press.

2023年

Inagaki FF, Wakiyama H, Furusawa A, Okada R, Kato T, Fujimura D, Okuyama S,
Fukushima H, Takao S, Choyke PL, Kobayashi H.
Near-infrared photoimmunotherapy (NIR-PIT) of bone metastases in an animal model.
Biomedicine & Pharmacotherapy 2023 ;160:114390. doi: 10.1016/j.biopha.2023.114390.
Kato T, Riahin C, Furusawa A, Fukushima H, Wakiyama H, Okuyama S, Takao S,
Choyke PL, Ptaszek M, Rosenzweig Z, Kobayashi H.
Simultaneous Multicolor Imaging of Lymph Node Chains using Hydroporphyrin-Doped
Near-Infrared-Emitting Polymer Dots.
Nanomedicine (London) 2023; 18(8):659-666
Iwase T, Ito K, Nishimura T, Miyakawa K, Ryo A, Kobayashi H, Mitsunaga M.
Photoimmunotechnology as a powerful biological tool for molecular-based elimination of
target microbes and cells.
Nature Protocol 2023;18(11):3390-3412.
Fukushima H, Furusawa A, Kato T, Wakiyama H, Takao S, Okuyama S, Choyke PL,
Kobayashi H.
Intratumoral interleukin-15 improves efficacy of near-infrared photoimmunotherapy.
Molecular Cancer Therapeutics 2023; 22(10):1215-1227.
Takao S, Fukushima H, King AP, Kato T, Furusawa A, Okuyama S, Kano M, Choyke
PL, Escorcia FE, Kobayashi H.
Near-infrared Photoimmunotherapy in a Model of Hepatocellular Carcinoma using
Cetuximab-IR700.
Cancer Science 2023; In press.
Miyazaki NL, Furusawa A, Choyke PL, Kobayashi H.
Review of RM-1929 near infrared photoimmunotherapy clinical efficacy for unresectable
and/or recurrent head and neck squamous cell carcinoma.
Cancers 2023; 15(21): 5117.
Kato T, Furusawa A, Okada R, Inagaki F, Wakiyama H, Furumoto H, Fukushima H,
Okuyama S, Choyke PL, Kobayashi H.
Near-infrared photoimmunotherapy targeting podoplanin-expressing cancer cells and
cancer-associated fibroblasts
Molecular Cancer Therapeutics 2023 Jan 3;22(1):75-88. doi: 10.1158/1535-7163.MCT-22-
0313.

2022年

Okada R, Kato T, Furusawa A, Inagaki F, Wakiyama H, Fujimura D, Okuyama S,
Furumoto H, Fukushima H, Choyke PL, Kobayashi H.
Selection of antibody and light exposure regimens alters therapeutic effects of EGFRtargeted near-infrared photoimmunotherapy.
Cancer Immunology Immunotherapy 2022 ;71(8):1877-1887. doi: 10.1007/s00262-021-
03124-x.
Furusawa A, Okada R, Inagaki F, Wakiyama H, Kato T, Choyke PL, Kobayashi H
CD29 targeted near-infrared photoimmunotherapy (NIR-PIT) in the treatment of a
pigmented melanoma model
Oncoimmunology 2022 ;11(1):2019922. doi: 10.1080/2162402X.2021.2019922
Jin J, Krishnamachary B, Mironchik Y, Sivakumar I, Wildes F, Barnett JD, Hung C-F,
Nimmagadda S, Kobayashi H, Bhujwalla ZM, Penet M-F.
PD-L1 Near Infrared Photoimmunotherapy of Ovarian Cancer Model
Cancers 2022 ;14(3):619. doi: 10.3390/cancers14030619.
Tazawa H, Shigeyasu K, Noma K, Kagawa S, Kobayashi H, Imamura T, Fujiwara T.
Tumor-targeted fluorescence imaging systems for diagnosis and treatment of cancer.
Cancer Science 2022 ;113(6):1919-1929. doi: 10.1111/cas.15369.
Wakiyama H, Furusawa A, Okada R, Inagaki F, Kato T, Furumoto H, Fukushima H,
Okuyama S, Choyke PL, Kobayashi H.
Opening up new VISTAs: V-domain Immunoglobulin Suppressor of T cell Activation
(VISTA) targeted near-infrared photoimmunotherapy (NIR-PIT) for enhancing host
immunity against cancers.
Cancer Immunology Immunotherapy 2022 ;71(12):2869-2879. doi: 10.1007/s00262-022-
03205-5.
. Moriya T, Hashimoto M, Matsushita H, Masuyama S, Yoshida R, Okada R, Furusawa
A, Fujimura D, Wakiyama H, Kato T, Choyke PL, Kusumoto Y, Chtanova T, Kobayashi
H, Tomura M.
Near-infrared photoimmunotherapy induced tumor cell death enhances tumor dendritic cell
migration.
Cancer Immunology Immunotherapy 2022 ;71(12):3099-3106. doi: 10.1007/s00262-022-
03216-2.
Fukushima H, Matikonda SS, Usama SM, Furusawa A, Kato T, Štacková L, Klán P,
Kobayashi H, Schnermann MJ.
Cell labeling with spatiotemporal control using cyanine phototruncation
2
Journal of the American Chemical Society 2022 ;144(25):11075-11080. doi:
10.1021/jacs.2c02962.
Fukushima H, Kato T, Furusawa A, Okada R, Wakiyama H, Furumoto H, Okuyama S,
Kondo E, Choyke PL, Kobayashi H.
Intercellular adhesion molecule-1 (ICAM-1)-targeted near-infrared photoimmunotherapy in
the treatment of triple-negative breast cancer.
Cancer Science 2022 ;113(9):3180-3192. doi: 10.1111/cas.15466.
Kato T, Okada R, Furusawa A, Wakiyama H, Furumoto H, Fukushima H, Okuyama S,
Choyke PL, Kobayashi H.
A comparison of the effectiveness of IgG antibody vs. F(ab’)2 antibody fragment in
CTLA4-targeted near-infrared photoimmunotherapy
Molecular Pharmaceutics 2022 ;19(10):3600-3611. doi:
10.1021/acs.molpharmaceut.2c00242.
Mitsunaga M, Ito K, Nishimura T, Miyata H, Miyakawa K, Morita T, Ryo A,
Kobayashi H, Mizunoe Y, Iwase T.
Evidence of a targeted antimicrobial therapeutic strategy against different bacterial, fungal,
and viral pathogens.
Commission Biology 2022 ;5(1):647. doi: 10.1038/s42003-022-03586-4.
Takahashi K, Yasui H, Taki S, Shimizu M, Koike C, Taki K, Hiroshi Y, Baba Y,
Kobayashi H, Sato K.
Near-infrared-induced drug release from antibody-drug double conjugates exerts a
cytotoxic photo-bystander effect.
Bioengineering and Translational Medicine 2022 ;7(3):e10388. doi: 10.1002/btm2.10388.
Barnett JD, Jin J, Penet M-F, Kobayashi H, Bhujwalla ZM.
Phototheranostics of splenic myeloid-derived suppressor cells and its impact on spleen
metabolism in tumor-bearing mice.
Cancers 2022;14(15):3578. doi: 10.3390/cancers14153578.
Furumoto H, Okada R, Kato T, Wakiyama H, Inagaki F, Fukushima H, Okuyama S,
Furusawa A, Choyke PL, Kobayashi H.
Optimal light dose for hEGFR-targeted near-infrared photoimmunotherapy.
Cancers 2022;14(16):4042. doi: 10.3390/cancers14164042.
Jin J, Barnett JD, Krishnamachary B, Mironchik Y, Luo C, Kobayashi H, Bhujwalla
ZM.
Targeting cancer associated fibroblasts by photoimmunotheranostics of fibroblast activation
protein-α
Cancer Science 2022 2023 Jan;114(1):236-246. doi: 10.1111/cas.15601.
Inagaki FF, Kato T, Furusawa A, Okada R, Wakiyama H, Furumoto H, Okuyama S,
Choyke PL, Kobayashi H.
Disialoganglioside GD2-targeted near-infrared photoimmunotherapy (NIR-PIT) in tumors
of neuroectodermal origin.
Pharmaceutics 2022 ;14(10):2037. doi: 10.3390/pharmaceutics14102037.
Wakiyama H, Furusawa A, Okada R, Inagaki F, Kato T, Furumoto H, Fukushima H,
Okuyama S, Choyke PL, Kobayashi H.
Treg-dominant tumor microenvironment is responsible for hyperprogressive disease after
PD-1 blockade therapy
Cancer Immunology Research 2022 ;10(11):1386-1397. doi: 10.1158/2326-6066.CIR-22-
0041.
Sato H, Noma K, Ohara T, Kawasaki K, Akai M, Kobayashi T, Nishiwaki N,
Narusaka T, Komoto S, Kashima H, Katsura Y, Kato T, Kikuchi S, Tazawa H, Kagawa S,
Shirakawa Y, Kobayashi H, Fujiwara T.
Dual-targeted near-infrared photoimmunotherapy for esophageal cancer and cancerassociated fibroblasts in the tumor microenvironment.
Scientific Reports 2022 ;12(1):20152. doi: 10.1038/s41598-022-24313-3.
Kato T, Fukushima H, Furusawa A, Okada R, Wakiyama H, Furumoto H, Okuyama S,
Takao S, Choyke PL, Kobayashi H.
Selective depletion of polymorphonuclear myeloid derived suppressor cells in tumor beds
with near infrared photoimmunotherapy enhances host immune response.
OncoImmunology 2022 ;11(1):2152248. doi: 10.1080/2162402X.2022.2152248