業績

Result

2024年

  1. Mitsui A, Iioka H, Ling Y, Okuda S, Kurose A, Schopperle M, Kondo T, Sakaguchi M, Saito K, Kondo E.: Pathological and Biological Significance of the Specific Glycan, TRA-1-60, on Aggressive Gastric Adenocarcinoma.

    Lab Invest. 2024 Jul;104(7):102073. doi: 10.1016/j.labinv.2024.102073. Epub 2024 May 6.

  2. Jiang F, ChenY, Tomonobu N, Kinoshita R, Yoni Komalasari N-L-G, Kasano-Camones C-I, Ninomiya K, Murata H, Yamamoto K, Gohara Y, Ochi T, Ruma I-M-W, Sumardika I-W, Zhou J, Honjo T, Sakaguchi Y, Yamauchi A, Kuribayashi F, Futami J, Kondo E, Inoue Y, Toyooka S, Sakaguchi M: Dissection of the signal transduction machinery responsible for the lysyl oxidase-like 4-mediated increase in invasive motility in triple-negative breast cancer cells: mechanistic insight into the integrin-β1-NF-κB-MMP9 axis

    Front Oncol. 2024 May 28:14:1371307. doi: 10.3389/fonc.2024.1371307.

  3. Takahashi T, Tomonobu N, Kinoshita R, Yamamoto K, Murata H, Yoni Komalasari N-L-G, Chen Y, Jiang F, Gohara Y, Ochi T, Winarsa Ruma I-M, Sumardika I-W, Zhou J, Honjo T, Sakaguchi Y, Yamauchi A, Kuribayashi F, Kondo E, Inoue Y, Futami J, Toyooka S, Zamami Y, Sakaguchi M.: Lysyl oxidase-like 4 promotes the invasiveness of triple-negative breast cancer cells by orchestrating the invasive machinery formed by annexin A2 and S100A11 on the cell surface.

    Front Oncol. 2024 Mar 26:14:1371342. doi: 10.3389/fonc.2024.1371342.

2023年

  1. Fujisaki T, Saito K, Kikuchi T, Kondo E.: The prolyl hydroxylase OGFOD1 promotes cancer cell proliferation by regulating the expression of cell cycle regulators.
    FEBS Lett. 2023 Apr;597(8):1073-1085. doi: 10.1002/1873-3468.14547.

2022年

  1. Fukushima H, Kato T, Furusawa A, Okada R, Wakiyama H, Furumoto H, Okuyama S, Kondo E, Choyke PL, Kobayashi H.: Intercellular adhesion molecule-1-targeted near-infrared photoimmunotherapy of triple-negative breast cancer.
    Cancer Sci. 2022 Sep;113(9):3180-3192. doi: 10.1111/cas.15466.

  2. Tomonobu N, Kinoshita R, Wake H, Inoue Y, Ruma I-M W, Suzawa K, Gohara Y, Komalasari NLGY, Jiang F, Murata H, Yamamoto K, Sumardika IW, Chen Y, Futami J, Yamauchi A, Kuribayashi F, Kondo E, Toyooka S, Nishibori M, Sakaguchi M.: Histidine-rich Glycoprotein suppresses the S100A8/A9-mediated organotropic metastasis of melanoma cells.
    Int J Mol Sci. 2022 Sep 7;23(18):10300. doi: 10.3390/ijms231810300.

  3. Herik Rodrigo AG, Tomonobu N, Yoneda H, Kinoshita R, Mitsui Y, Sadahira T, Terawaki SI, Gohara Y, Gede Yoni Komalasari NL, Jiang F, Murata H, Yamamoto KI, Futami J, Yamauchi A, Kuribayashi F, Inoue Y, Kondo E, Toyooka S, Nishibori M, Watanabe M, Nasu Y, Sakaguchi M. : Toll-like receptor 4 promotes bladder cancer progression upon S100A8/A9 binding, which requires TIRAP-mediated TPL2 activation.
    Biochem Biophys Res Commun. 2022 Dec 17;634:83-91. doi:10.1016/j.bbrc.2022.09.116. Epub 2022 Oct 6.

  4. Yokoyama Y, Iioka H, Horii A, Kondo E. Crumbs3 is expressed in oral squamous cell carcinomas and promotes cell migration and proliferation by affecting RhoA activity.
    Oncol Lett. 2022 Jun;23(6):173. doi: 10.3892/ol.2022.13293.

2021年

  1. Saito K, Mitsui A, Sumardika IW, Yokoyama Y, Sakaguchi M, Kondo E*. PLOD2-driven IL-6/STAT3 signaling promotes the invasion and metastasis of oral squamous cell carcinoma via activation of integrin β1.

    Int J Oncol. 2021 Jun;58(6):29. doi: 10.3892/ijo.2021.5209. Epub 2021 Apr 23.

  2. Kondo E*, Iioka H, Saito K. : Tumor-homing peptide and its utility for advanced cancer medicine.

    Cancer Sci. 2021 Jun;112(6):2118-2125. doi: 10.1111/cas.14909. Epub 2021 May 7

2020年

  1. Ueki Y, Saito K, Iioka H, Sakamoto I, Kanda Y, Sakaguchi M, Horii A, Kondo E*.: PLOD2 Is Essential to Functional Activation of Integrin β1 for Invasion/Metastasis in Head and Neck Squamous Cell Carcinomas.

    iScience. 2020 Feb 21;23(2):100850. doi: 10.1016 /j.isci.2020.100850.

2019年

  1. Iioka H, Saito K, Sakaguchi M, Tachibana T, Homma K, Kondo E. Crumbs3 is a critical factor that regulates invasion and metastasis of colon adenocarcinoma via the specific interaction with FGFR1.

    Int J Cancer. 2019 Nov 15;145(10):2740-2753. doi: 10.1002/ijc.32336. Epub 2019 Apr 29. PMID:30980524

     

  2. Saito K, Iioka H, Maruyama S, Sumardika IW, Sakaguchi M, Kondo E.

    PODXL1 promotes metastasis of the pancreatic ductal adenocarcinoma by activating the C5aR/C5a axis from the tumor microenvironment.

    Neoplasia. 2019 Nov 20;21(12):1121-1132. doi: 10.1016/j.neo.2019.09.003. [Epub ahead of print]　PMID:31759250

  3. Iioka H, Saito K, Kondo E. Crumbs3 regulates the expression of glycosphingolipids on the plasma membrane to promote colon cancer cell migration.

    Biochem Biophys Res Commun. 2019 Sep 6. pii: S0006-291X(19)31697-3. doi: 10.1016/j.bbrc.2019.08.161. [Epub ahead of print] PMID:31500807

  4. Mitsui Y, Tomonobu N, Watanabe M, Kinoshita R, Sumardika IW, Youyi C, Murata H, Yamamoto KI, Sadahira T, Rodrigo AGH, Takamatsu H, Araki K, Yamauchi A, Yamamura M, Fujiwara H, Inoue Y, Futami J, Saito K, Iioka H, Kondo E, Nishibori M, Toyooka S, Yamamoto Y, Nasu Y, Sakaguchi M. Upregulation of Mobility in Pancreatic Cancer Cells by Secreted S100A11 Through Activation of Surrounding Fibroblasts.

    Oncol Res. 2019 Aug 8;27(8):945-956. doi: 10.3727/096504019X15555408784978. Epub 2019 Apr 17. PMID:31046874

  5. Chen Y, Sumardika IW, Tomonobu N, Kinoshita R, Inoue Y, Iioka H, Mitsui Y, Saito K, Ruma IMW, Sato H, Yamauchi A, Murata H, Yamamoto KI, Tomida S, Shien K, Yamamoto H, Soh J, Futami J, Kubo M, Putranto EW, Murakami T, Liu M, Hibino T, Nishibori M, Kondo E, Toyooka S, Sakaguchi M. Critical role of the MCAM-ETV4 axis triggered by extracellular S100A8/A9 in breast cancer aggressiveness.

    Neoplasia. 2019 Jul;21(7):627-640. doi: 10.1016/j.neo.2019.04.006. Epub 2019 May 14. PMID:31100639

  6. Takamatsu H, Yamamoto KI, Tomonobu N, Murata H, Inoue Y, Yamauchi A, Sumardika IW, Chen Y, Kinoshita R, Yamamura M, Fujiwara H, Mitsui Y, Araki K, Futami J, Saito K, Iioka H, Ruma IMW, Putranto EW, Nishibori M, Kondo E, Yamamoto Y, Toyooka S, Sakaguchi M. Extracellular S100A11 Plays a Critical Role in Spread of the Fibroblast Population in Pancreatic Cancers.

    Oncol Res. 2019 Jun 21;27(6):713-727. doi: 10.3727/096504018X15433161908259. Epub 2019 Mar 8.

  7. Takata K, Saito K, Maruyama S, Miyata-Takata T, Iioka H, Okuda S, Ling Y, Karube K, Miki Y, Maeda Y, Yoshino T, Steidl C, Kondo E. Identification of TRA-1-60-positive cells as a potent refractory population in follicular lymphomas. 

    Cancer Sci. 2019 Jan;110(1):443-457. doi: 10.1111/cas.13870. Epub 2018 Dec 8. PMID:30417470

2018年

  1. Saito K, Sakaguchi M, Maruyama S, Iioka H, Putranto EW, Sum dika IW, Tomonobu N, Kawasaki T, Homma K, Kondo E. Stromal mesenchymal stem cells facilitate pancreatic cancer progression by regulating specific secretory molecules through mutual cellular interaction. 

    J Cancer. 2018 Jul 30;9(16):2916-2929. doi: 10.7150/jca.24415. eCollection 2018. PMID:30123360

  2. Kanda Y, Takeuchi A, Ozawa M, Kurosawa Y, Kawamura T, Bogdanova D, Iioka H, Kondo E, Kitazawa Y, Ueta H, Matsuno K, Kinashi T, Katakai T.: Visualizing the Rapid and Dynamic Elimination of Allogeneic T Cells in Secondary Lymphoid Organs.

    J Immunol, 2018 Aug 1;201(3):1062-1072. doi: 10.4049/jimmunol.1700219.

2016年

  1. Saito K, et al. Peptide-based tumor inhibitor encoding mitochondrial p14(ARF) is highly efficacious to diverse tumors.

    Cancer Sci. 2016 Sep;107(9):1290-301. doi: 10.1111/cas.12991.

2015年

  1. Higa M, Katagiri C, Shimizu-Okabe C, Tsumuraya T, Sunagawa M, Nakamura M, Ishiuchi S, Takayama C, Kondo E, Matsushita M.: Identification of a novel cell-penetrating peptide targeting human glioblastoma cell lines as a cancer-homing transporter.

    Biochem Biophys Res Commun. 457(2):206-12, 2015 doi: 10.1016/j.bbrc.2014.12.089.

2014年

  1. Saito K, et al. Coxsackie and adenovirus receptor is a critical regulator for the survival and growth of oral squamous carcinoma cells.

    Oncogene. 2014 Mar 6;33(10):1274-86. doi: 10.1038/onc.2013.66.

2013年

  1. Saito K, Takigawa N, Ohtani N, Iioka H, Tomita Y, Ueda R, Fukuoka J, Kuwahara K, Ichihara E, Kiura K and Kondo E.: Anti-tumor impact of p14ARF on gefitinib-resistant non-small cell lung cancers.

    Mol. Cancer Ther. 12(8):1616-1628, 2013 doi: 10.1158/1535-7163. (※Highlights of the issue.)

2012年

  1. Kondo E, et al. Tumour lineage-homing cell-penetrating peptides as anticancer molecular delivery systems.

    Nat Commun. 2012 Jul 17;3:951. doi: 10.1038/ncomms1952

  2. Fujii M, Toyoda T, Nakanishi H, Yatabe Y, Sato A, Matsudaira Y, Ito H, Murakami H, Kondo, Y., Kondo E, Hida T, Tsujimura T, Osada H, Sekido Y.; TGF-b synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth. 

    1. J. Exp. Med., Mar 12;209(3):479-94. 2012.

  3. Maseki, S, Ijichi K, Tanaka H, Fujii M, Hasegawa Y, Ogawa T, Murakami S, Kondo E, Nakanishi H.: Acquisition of EMT phenotype in the gefitinib-resistant cells of a head and neck squamous cell carcinoma cell line through Akt/GSK-3β/snail signaling pathway. 

    Br. J. Cancer, Mar 13;106(6):1196-20, 2012.

2011年

  1. Saito K, Kondo E and Matsushita M.: MicroRNA 130 family regulates the hypoxia response signal through the P-body protein DDX6.

    Nuc. Acid Res., 39(14):6086-99, 2011 doi: 10.1093/nar/gkr194. [Epub 2011 Apr 12.]

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